Previously, we developed the principle of constructing modular materials with specified properties, according to which organometallic composites, with nanoscale enzyme complexes introduced into them, are applied to a unified fabric platform. The resulting composites become a new platform for heterogeneous biocatalysis. Such a platform has high stability and good catalytic selectivity. The aim of the work is to study the properties of a unified fabric platform and to establish the possibility of giving materials (tissues) anti-chemical protective properties. The paper analyzes scientific and practical information on the production of composite fibrous materials with frame fibrous layers. The properties of a unified tissue platform and the mechanisms of protective action due to the enzymecontaining formulation applied to it are investigated. As a unified fabric platform on which other special modules are applied, it is proposed to use para-aramid protective fabric (Rusar fiber), as well as other types of fabrics – mixed aramid-viscose, aramid-cotton, aramid-polyacrylate, metaaramide (Nomex fiber). The physical properties and chemical structure of aromatic polyamides, possible directions for the production of aramid fibers, the structure and structure of aramid fibers, the mechanisms of chemical processes in polyinide compositions of various compositions are considered. Approaches to giving materials (tissues) anti-chemical protective properties are determined. The catalytic characteristics of fibrous materials functionalized by enzyme-polyelectrolyte complexes carrying out hydrolysis of organophosphorus compounds and mycotoxins have been studied.

The Iran-Iraq war (1980–1988) was the first modern war in which chemical weapons were used. The purpose of this work is to summarize the experience of treating victims, affected by nerve agents. The publications of Iranian authors in different scientific journals were used for the preparation of the article. The first use of chemical weapons by the Iraqi army occurred in August 1983 in Kurdistan (sulfur mustard). Nerve agent (tabun) was first used on February 29, 1984 in the battles for the Majnun Islands. In total, 140 tons of tabun and about 600 tons of sarin / cyclosarin were used against Iranian troops during the war. Around 5.5 thousand servicemen died directly from the nerve agents. For one dead from tabun, there were at least 7 poisoned people who needed qualified toxicological assistance; lethal outcomes among servicemen affected by the herd amounted to at least 15%. Military personnel without protective equipment, who received large doses of nerve agents, lost consciousness within 30 seconds and died in positions within a few minutes. The most sensitive to such agents were women, children and the elderly, who accidentally fell under a chemical attack. The use of nerve agents by the enemy was accompanied by panic in the troops and the arrival of a huge number of military personnel in critical condition at medical stations. Sweating, fasciculations and miosis were the first clinical signs by which those affected by such toxic agents were recognized. The effectiveness of antidote therapy (atropine + oxime + diazepam) depended on the time of medical care. The most effective was the use of atropine by titration (fractional intravenous drip) to achieve ease of breathing, absence of bronchospasm, disappearance of secretions from the respiratory tract and heart rate >80 beats/min. The oximes turned out to be not effective in the treatment of those poisoned by tabun. The most effective was degassing by physical removal of toxic chemical. Degassing of the affected had to be carried out by washing with sea or river water, using solutions of chlorine-containing household chemicals, and sprinkling with dry earth.

The collapse of the Soviet Union in 1991 led to the creation of 15 weak states that have on their territory the remnants of the defensive infrastructure of the mighty superpower – the USSR. The United States and its NATO allies have taken advantage of this situation to gain scientific and technical knowledge previously unknown to them and, through the Cooperative Threat Reduction (CTR) Program, have begun dismantling weapons of mass destruction-related facilities in the former republics of the Soviet Union. Under the pretext of reducing the risk of bioterrorism and preventing the spread of technologies and knowledge that allow the creation of biological weapons (BW), the United States surrounded Russia and Belarus with a network of biological laboratories subordinate to the US Department of Defense. The purpose of this work is to describe the real picture of the activities of American military biological laboratories in the states of the former USSR. Only open sources were used in the work. At least 50 US military biological laboratories along the perimeter of Russia and Belarus have been established: in Armenia – 12; at least 8 in Azerbaijan; at least 11 in Ukraine; in Moldavia – 1; in Georgia – 12; in Kazakhstan – 6; in Tajikistan – at least 4 large and an unknown number of small laboratories; in Uzbekistan – at least 8. Their dual purpose is evidenced by the fact that their activities, contrary to paragraph 10 of the Biological Weapons Convention, are kept secret. In these laboratories, work with dangerous coronaviruses, potential agents of biological weapons (plague, tularemia, hemorrhagic fevers, brucellosis, etc.) is underway. What is rather alarming, experiments are being conducted to restore the genome of the causative agent of the plague, which caused the «black death» pandemic in the XIV century (Kazakhstan, Alma-Ata). In addition, data on «strange» outbreaks of human and animal diseases, the emergence of previously unseen species of animals (mosquitoes, flies, bats ect.), agricultural disasters around these laboratories, indicate that Americans do not comply with expensive measures of special safety precautions necessary when working with dangerous pathogens. The latter circumstance poses a direct danger not only to the countries that have provided their territory for them, but also to Russia and Belarus. The problem of American biological laboratories around Russia and Belarus requires a radical solution for a long time.

During the COVID-19 pandemic the experts noted the emergence and periodic change of the dominant variants of the coronavirus (SARS-CoV-2) that caused the disease. The line B.1.1529, the omicron variant according to the WHO classification, became dominant in the fifth wave of the COVID-19 pandemic. The aim of the work is to analyze the properties of B.1.1529 (omicron) viruses that ensure its ability to cause disease in vaccinated or previously recovered from COVID-19. The fifth wave is characterized by the parallel distribution of the delta and omicron variants, with the domination of the latter. The omicron variant arose as a result of multiple passages of SARS-CoV-2 through the organisms of immunocompromised patients. If the delta variant is the most virulent for humans, the omicron variant is certainly the most infectious - the value of the basic reproductive number (R₀) for it is ≈ 10.0, for the delta variant ≈ 6, 0. A person infected with the omicron variant is capable of transmitting the SARS-CoV-2 virus within a day. This is caused by a combination of N501Y and Q498R mutations in the omicron variant, which increase the affinity of the receptor-binding domain of the S1 subunit of the viral S protein for the ACE-2 receptor in the human lung. Mutations H655Y and N679K are located near the furin cleavage site, which in turn promotes accelerated cleavage of the S-protein and increases the level of infectiousness of the pathogen. The omicron variant is significantly superior to the delta variant in terms of ability to overcome the immunity caused by vaccination. The spread of the disease was not stopped by the fact that the number of people who completed the full course of vaccination at the beginning of the fifth wave in Russia reached 64%.Therefore, the achieved level of vaccination cannot be considered sufficient to stop the spread of this variant of the virus. It is shown in the article, that this indicator should be at least 80% to prevent the spread of the disease, and only if vaccination is carried out in a short time. However, it is possible that the mutational potential of the SARS-CoV-2 virus has not yet been exhausted, and the pandemic on the omicron variant will not end.

Reverse transcription-real-time polymerase chain reaction (RT-PCR) is currently the leading laboratory diagnostic tool for COVID-19. With the help of RT-PCR-RT, diagnostics is carried out at the early stages of the development of the disease. The studied clinical samples, as a rule, are swabs from the pharynx and nasopharynx. The aim of the work is to identify and analyze the factors that contribute to false negative results when diagnosing COVID-19 by RT-PCR-RT. It is shown in the article, that the analytical sensitivity of the real-time RT-PCR method is not the main factor in assessing the possibility of obtaining false negative results. The paper considers the effect of drinking hot drinks (tea, coffee), alcohol and smoking (immediately before sampling) on the results of the analysis of swabs from the pharynx and nasopharynx by RT-PCR RT. It was found that the intake of hot drinks before sampling (the probability of obtaining a false negative result is at least 80%) influences most of all on the possibility of obtaining a false negative result in RT-PCR-RT in swabs from the pharynx. The use of small doses of alcohol (0.25–0.33 g of ethanol per 1 kg of body weight) has a lesser effect. Smoking immediately prior to sample collection does not lead to a false negative result in real-time RT-PCR. None of the considered influences affects the possibility of obtaining false negative results in the analysis of swabs from the nasopharynx. Recommendations were made on the need for simultaneous examination of both throat swabs and nasopharyngeal swabs in the ongoing diagnosis of COVID-19.