History of the Сreation of Home Built Equipment for the Industrial Cultivation of Microorganisms
https://doi.org/10.35825/2587-5728-2018-2-1-37-47
EDN: yoiieh
Abstract
A bioreactor (cultivator or fermenter) is one of the main elements of the vast majority of instrumentation-technological lines of immunological medicinal preparations. The construction of special equipment for industrial microbiology in our country was determined by the research, related to the development of technology of the production of live plaque vaccine. In the early 1930’s A.L. Berlin studied the approaches to the creation of laboratory cultivating devices in the city of Saratov on the basis of the State Regional Institute of Microbiology and Epidemiology of the SouthEast of Russia, the People's Commissariat of Health of the RSFSR. At the same time this problem has been solved by N.G. Shcherbina in the Crimean Sanitary-Bacteriological Institute (Sevastopol). In 1936, a group of researchers from the Scientific Research Institute of Epidemiology and Hygiene of the Red Army (Kirov) was involved in the research of the processes and technologies of the industrial microbiology. In 1946 the first industrial apparatus of A.F. Shesterenko under sterile conditions ensured the production of large volumes (up to 800 mattresses) of the culture of the vaccine strain EV of the NIIEG line of the plague microbe.
About the Authors
A. A. LeshchenkoRussian Federation
Leading Researcher of the Scientific and Research Department. Doctor of Technical Sciences, Professor
Oktyabrsky Avenue 119, Kirov 610000
A. S. Tumanov
Russian Federation
Chief of the Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation. Candidate of Medical Sciences
Oktyabrsky Avenue 119, Kirov 610000
D. A. Sharov
Russian Federation
Chief of the Scientific and Research Department. Candidate of Technical Sciences
Oktyabrsky Avenue 119, Kirov 610000
S. V. Bagin
Russian Federation
Researcher of the Scientific and Research Department. Candidate of Technical Sciences
Oktyabrsky Avenue 119, Kirov 610000
S. V. Logvinov
Russian Federation
Researcher of the Scientific and Research Department. Candidate of Biological Sciences
Oktyabrsky Avenue 119, Kirov 610000
I. P. Pogorelsky
Russian Federation
Leading Researcher of the Scientific and Research Department. Doctor of Medical Sciences, Professor
Oktyabrsky Avenue 119, Kirov 610000
A. G. Lazykin
Russian Federation
Senior Researcher of the Scientific and Research Department. Candidate of Biological Sciences
Oktyabrsky Avenue 119, Kirov 610000
A. V. Ezhov
Russian Federation
Senior Researcher of the Scientific and Research Department. Doctor of Medical Sciences, Senior Researcher
Oktyabrsky Avenue 119, Kirov 610000
D. A. Mokhov
Russian Federation
Researcher of the Scientific and Research Department. Candidate of Biological Sciences
Oktyabrsky Avenue 119, Kirov 610000
V. V. Krupin
Russian Federation
Deputy Head of the Department of the Scientific and Research Department. Candidate of Biological Sciences
Oktyabrsky Avenue 119, Kirov 610000
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Review
For citations:
Leshchenko A.A., Tumanov A.S., Sharov D.A., Bagin S.V., Logvinov S.V., Pogorelsky I.P., Lazykin A.G., Ezhov A.V., Mokhov D.A., Krupin V.V. History of the Сreation of Home Built Equipment for the Industrial Cultivation of Microorganisms. Journal of NBC Protection Corps. 2018;2(1):37-47. (In Russ.) https://doi.org/10.35825/2587-5728-2018-2-1-37-47. EDN: yoiieh