The Improvement of Live Plaque Vaccine Production Technology
https://doi.org/10.35825/2587-5728-2017-1-3-30-37
EDN: yoqcct
Abstract
The article is dedicated to the possible improvement of the production technology of live plaque vaccines. The automated information system (AIS) of the control of the production of pharmaceuticals has been elaborated in the branch office of the «48 Central Scientific Research Institute» of the Ministry of Defence of Russia (Kirov) within the framework of the federal target program «The National System of Chemical and Biological Security of the Russian Federation». The AIS has been used for the improvement of the technology of submerged cultivation of live plaque vaccine. Strain EV, line NIIEG, as well as the upgraded fermenter BIOR-0,25 with the AIS of the control of the production have been used in this work. The problems of the improvement of the production technology of pharmaceuticals have been studied. The possibility of shared use of the fermenters and AIS of the control of the production of pharmaceuticals has been proven experimentally. This hardware system can accumulate, systemize and record scientific and technical information about all the operations. The above-mentioned studies allow to enhance the technological capabilities of the equipment and to improve the stage of the submerged cultivation in the production of live plaque vaccine.
About the Authors
D. A. Sharov
Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Chief of the Scientific and Research Department. Candidate of Technical Sciences
Oktyabrsky Avenue 119, Kirov 610000
A. A. Leshchenko
Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Leading Researcher of the Scientific and Research Department. Doctor of Technical Sciences, Professor
Oktyabrsky Avenue 119, Kirov 610000
C. V. Bagin
Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Researcher of the Scientific and Research Department. Candidate of Technical Sciences
Oktyabrsky Avenue 119, Kirov 610000
S. V. Logvinov
Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Researcher of the Scientific and Research Department. Candidate of Biological Sciences
Oktyabrsky Avenue 119, Kirov 610000
A. V. Ezhov
Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Senior Researcher of the Scientific and Research Department. Doctor of Medical Sciences, Senior Researcher
Oktyabrsky Avenue 119, Kirov 610000
A. G. Lazykin
Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Senior Researcher of the Scientific and Research Department. Candidate of Biological Sciences
Oktyabrsky Avenue 119, Kirov 610000
D. A. Mokhov
Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Researcher of the Scientific and Research Department. Candidate of Biological Sciences
Oktyabrsky Avenue 119, Kirov 610000
V. V. Krupin
Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Deputy Head of the Scientific and Research Department. Candidate of Biological Sciences
Oktyabrsky Avenue 119, Kirov 610000
A. R. Ziganshin
Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Senior Researcher of the Scientific and Research Department
Oktyabrsky Avenue 119, Kirov 610000
References
1. Selevtsov L.I. Automation of technological processes. Moscow: Academy, 2014. 352 p. (in Russian).
2. Tumanov Yu.V., Boldyrev A.N., Autenshlyus A.I. Medical Biotechnology: diagnostics of diseases and the creation of pharmaceuticals. Novosibirsk: Publ. NSTU, 2016. 214 p. (in Russian).
3. Patent RF 2510825 (2013) (in Russian).
4. Lakin G.F. Biometrics. Moscow: Higher School, 1990 (in Russian)
5. Bezborodov A.M., Zagustina N.A., Popov V.O. Enzymatic processes in biotechnology. Moscow: Nauka, 2008. 335 p. (in Russian).
6. Operation and maintenance of pharmaceutical equipment. Manual. URL: http://www.Biotechno.ru/2016/catalog/87.html (in Russian).
7. ОSТ 64-02-003-2002. Medical industry products. Technological regulations of the production. The contents, the order of development, coordination and approval. Introd. 15.04.2003. Мoscow, 2003 (in Russian).
8. Pharmacopeial article of the enterprise LP-000535 «Live plaque vaccine, lyophilizate for the production of the suspension for injections, inhalations and dermal scarifying application» (in Russian). Introd. 12.05.2011.
Review
For citations:
Sharov D.A., Leshchenko A.A., Bagin C.V., Logvinov S.V., Ezhov A.V., Lazykin A.G., Mokhov D.A., Krupin V.V., Ziganshin A.R. The Improvement of Live Plaque Vaccine Production Technology. Journal of NBC Protection Corps. 2017;1(3):30-37. (In Russ.) https://doi.org/10.35825/2587-5728-2017-1-3-30-37. EDN: yoqcct
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