Study of Antidote Activity of Zinc Ascorbate in Acute Mercury Lesions
https://doi.org/10.35825/2587-5728-2017-1-2-14-23
EDN: yoqbyt
Abstract
The article is dedicated to the study on the antidote activity of zinc ascorbate (С6Н8О4Zn) in acute mercury lesions. Biologically active zinc-containing substance – zinc ascorbate – is synthesized. It is determined that in case of acute mercury lesions the survival rates are much higher (from 10 to 67 %) for those experimental animals, which preliminarily have been treated with the therapeutic doses of zinc ascorbate, and their peripheral blood parameters (the percentage of dead leukocytes, the content of toxic granules in leukocytes, sulfhydryl groups in leukocytes and free sulfhydryl groups in blood serum) are close to the physiological norm. These data show that zync salt of ascorbic acid definitely can protect from toxic effects of mercury and can be used as a prophylactic antidote in case of the subsequent acute mercury lesion.
About the Authors
A. A. Baranets
The Federal State Official Military Educational Establishment of Higher Education «Military Academy of Radiological, Chemical and Biological Defence named after Marshal of the Soviet Union S.K. Timoshenko»
Russian Federation
Russian Federation
Baranets Alexander Alexandrovich. Senior Researcher. Candidate of Medical Sciences
Gorky Street 16, Kostroma 156013
G. A. Prigorelov
The Federal State Official Military Educational Establishment of Higher Education «Military Academy of Radiological, Chemical and Biological Defence named after Marshal of the Soviet Union S.K. Timoshenko»
Russian Federation
Russian Federation
Candidate of Chemical Sciences. Associate Professor
Gorky Street 16, Kostroma 156013
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Review
For citations:
Baranets A.A., Prigorelov G.A. Study of Antidote Activity of Zinc Ascorbate in Acute Mercury Lesions. Journal of NBC Protection Corps. 2017;1(2):14-20. (In Russ.) https://doi.org/10.35825/2587-5728-2017-1-2-14-23. EDN: yoqbyt
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