A New Method for Early Diagnostics of Pathological States under the Action of Physiologically Active Substances with Genotoxic Properties upon Organism
https://doi.org/10.35825/2587-5728-2017-1-1-15-22
EDN: yoiiax
Abstract
The article is dedicated to the new method for early diagnostics of pathological conditions under the action of physiologically active substances with genotoxic properties. The method allows the evaluation of microsomal system of the liver under the action of xenobiotic alkylating type and the condition of microsomal oxidiation system in vivo. It is supposed to asses preliminary the norm of the reaction of organism (phenotype of bio-object) by the intensity of microsomal oxidiation during the study of the toxicological characteristics of physiologically active substances influencing the organism at low doses. The method includes the characteristics of hereditary intensity of epoxidiation (hydroxyliation) reactions of metabolism. Carbamazepine is used as a pharmacological probe. The article formulates the definition of the concept of norm, threshold for the harmful effect and prepatological state of organism.
About the Author
O. M. Antonova
Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Antonova Olga Mikhailovna. Leading Researcher. Doctor of Biological Sciences
Krasnoznamennaya Street 1, Volsk-18, Saratov Region 412918
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Review
For citations:
Antonova O.M. A New Method for Early Diagnostics of Pathological States under the Action of Physiologically Active Substances with Genotoxic Properties upon Organism. Journal of NBC Protection Corps. 2017;1(1):15-22. (In Russ.) https://doi.org/10.35825/2587-5728-2017-1-1-15-22. EDN: yoiiax
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