nbsprotВестник войск РХБ защитыJournal of NBC Protection Corps2587-57283034-279127 Научный центр10.35825/2587-5728-2023-7-3-237-247wdghbhnbsprot-319Research ArticleРАДИАЦИОННАЯ БЕЗОПАСНОСТЬ И ЗАЩИТА ОТ ЯДЕРНОГО ОРУЖИЯRADIATION SAFETY AND NUCLEAR WEAPONS DEFENSEРеакционные пути окислительной трансформации радиопротектора кверцетинаReaction Pathways of Oxidative Transformation of the Radioprotector Quercetinhttps://orcid.org/0009-0004-6866-218XОличеваВ. В.OlichevaV. V.

Оличева Вера Владимировна, студентка Института Фармации им. А.П. Нелюбина

119048, г. Москва, ул. Трубецкая, д. 8, стр. 2

Vera V. Olicheva, student. Institute of Pharmacy named after A.P. Nelyubin, Sechenov University

Trubetskaya Str., 8-2, Moscow 119991

vera.olicheva@inbox.ruhttps://orcid.org/0009-0003-3252-6322ТитоваА. Д.TitovaA. D.

Титова Александра Дмитриевна, аспирантка

119991, г. Москва, Ленинский проспект, д. 47

Alexandra D. Titova, postgrauate

Leninsky Avenue, 47, Moscow 119991

secretary@ioc.ac.ruhttps://orcid.org/0000-0001-9822-3322ИльясовИ. Р.IlyasovI. R.

Ильясов Игорь Равилевич, доцент кафедры химии Института Фармации им. А.П. Нелюбина, канд. фарм. наук, доцент

119048, г. Москва, ул. Трубецкая, д. 8, стр. 2

Igor R. Iyasov, Associate Professor. Department of Chemistry. Institute of Pharmacy named after A.P. Nelyubin, Sechenov University. Cand. Sci. (Pharm.), Associate Professor

Trubetskaya Str., 8-2, Moscow 119991

rectorat@staff.sechenov.ruФатеенковВ. Н.FateenkovV. N.

Фатеенков Владимир Николаевич, начальник отдела, канд. воен. наук, доцент, профессор АВН

111024, г. Москва, проезд Энтузиастов, д. 19

Vladimir N. Fateenkov, head of Department. Cand. Sci. (Military), Associate Professor, Professor at the AMS

Entuziastov Passage, 19, Moscow 111024

27nc_1@mil.ruБраунА. В.BraunA. V.

Браун Аркадий Владимирович, старший научный сотрудник, канд. хим. наук

111024, г. Москва, проезд Энтузиастов, д. 19

Arkadii V. Braun, research associate. Cand. Sci. (Chem.)

Entuziastov Passage, 19, Moscow 111024

27nc_1@mil.ruФедеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияFederal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University» of the Ministry of Health of the Russian Federation (Sechenov University)Russian FederationФедеральное государственное бюджетное учреждение науки «Институт органической химии им. Н.Д. Зелинского Российской академии наук»РоссияFederal State Budgetary Establishment «N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences»Russian FederationФедеральное государственное бюджетное учреждение «27 Научный центр» Министерства обороны Российской ФедерацииРоссияFederal State Budgetary Establishment «27 Scientific Centre» of the Ministry of Defence of the Russian FederationRussian Federation20230801202473237247Copyright © Оличева В.В., Титова А.Д., Ильясов И.Р., Фатеенков В.Н., Браун А.В., 20242024Оличева В.В., Титова А.Д., Ильясов И.Р., Фатеенков В.Н., Браун А.В.Olicheva V.V., Titova A.D., Ilyasov I.R., Fateenkov V.N., Braun A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nbsprot.ru/jour/article/view/319

Кверцетин является одним из наиболее перспективных природных полифенольных радиопротекторных соединений. Это свойство основано на его радикал-улавливающей активности и высокой антиоксидантной емкости, в проявлении которой значительную роль играют продукты окислительной деградации кверцетина. Образование специфических метаболитов в процессе окисления кверцетина может обуславливать не только его радиопротекторные свойства, но и токсические проявления. Цель работы – обобщение полученных ранее данных в отношении реакционных путей окислительной трансформации кверцетина. Материалы и методы. Использовали общедоступные научные публикации, посвященные изучению процессов трансформации кверцетина. Метод анализа – описательный. Обсуждение результатов. Представлен обзор научных работ, посвященных кислородному окислению, радикал-инициируемого окисления, электрохимического и ферментативного окислений, приведены возможные продукты трансформации кверцетина и механизмы их образования. Наиболее характерные пути окисления кверцетина обусловлены химической структурой колец, проявляющей специфическую реакционную способность. Выявлено влияние состава растворителей на продукты окисления при автоокислении кверцетина, в то время как радикальная и электрохимическая модели окисления отличаются наличием полимерных аддуктов. Попадая в живой организм, кверцетин может связывать свободные радикалы, предотвращая тем самым пагубное влияние радиации, то есть обладает свойствами радиопротектора. Выводы. Кверцетин можно рассматривать как потенциальный радиопротектор за счет способности связывать свободные радикалы, образующиеся в биологических жидкостях живых организмов, подвергшихся воздействию радиации.

Quercetin is one of the most promising natural polyphenolic radioprotective compounds. This property is based on its radical-scavenging activity and high antioxidant capacity, in the manifestation of which the products of oxidative degradation of quercetin play a significant role. The formation of specific metabolites during the oxidation of quercetin can determine not only its radioprotective properties, but also toxic manifestations. The purpose of this article is to summarize previously obtained data regarding the reaction pathways of oxidative transformation of quercetin. Materials and methods. We used publicly available scientific publications dedicated to the study of quercetin transformation processes. The method of analysis is descriptive. The discussion of the results. A review of scientific works dedicated to oxygen oxidation, radical-initiated oxidation, electrochemical and enzymatic oxidation is presented, possible transformation products of quercetin and the mechanisms of their formation are given. The most characteristic oxidation pathways of quercetin are determined by the chemical structure of the rings, which exhibit specific reactivity. The influence of the solvent composition on the oxidation products during the autoxidation of quercetin was revealed, while the radical and electrochemical models of oxidation differ in the presence of polymer adducts. Once in a living organism, quercetin can bind free radicals, thereby preventing the harmful effects of radiation, that is, it has the properties of a radioprotector. Conclusions. Quercetin can be considered as a potential radioprotector due to its ability to bind free radicals formed in the biological fluids of living organisms exposed to radiation.

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The authors declare that there are no conflicts of interest present.