nbsprotВестник войск РХБ защитыJournal of NBC Protection Corps2587-57283034-279127 Научный центр10.35825/2587-5728-2018-2-2-61-68yoqclbnbsprot-195Research ArticleБиологическая безопасность и защита от биологических угрозBiological Security and Protection against Biological ThreatsНекоторые опасные и особо опасные эмерджентные вирусные инфекции начала ХХI века: возникновение, распространение, опасность для здравоохраненияHazardous and Extremely Hazardous Emergent Viral Infections of the Beginning of XXI Century: Rise, Spread, Hazard for Public HealthБорисевичС. В.BorisevichS. V.

Борисевич Сергей Владимирович. Начальник Федерального государственного бюджетного учреждения «48 ЦНИИ» Минобороны России, д-р. биол. наук, проф., чл.-корр. РАН, полковник медицинской службы 

141306, г. Сергиев Посад, ул. Октябрьская, д. 11

Borisevich Sergey Vladimirovich.  Head of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation, Corresponding member of the Russian Academy of Sciences. Doctor of Biological Sciences, Professor 

Oktyabrskaya Street 11, Sergiev Posad 141306

48cnii@mail.ruСизиковаТ. Е.SizikovaT. E.

Сизикова Татьяна Евгеньевна. Научный сотрудник, канд. биол. наук 

141306, г. Сергиев Посад, ул. Октябрьская, д. 11

Researcher. Candidate of Biological Sciences 

Oktyabrskaya Street 11, Sergiev Posad 141306

СыромятниковаС. И.SyromyatnikovaS. I.

Сыромятникова Светлана Ивановна. Старший научный сотрудник, канд. биол. наук 

141306, г. Сергиев Посад, ул. Октябрьская, д. 11

Senior Researcher. Candidate of Biological Sciences 

Oktyabrskaya Street 11, Sergiev Posad 141306

ПантюховВ. Б.PantukhovV. B.

Пантюхов Владимир Борисович. Начальник научно-исследовательского управления, канд. мед. наук, полковник медицинской службы 

141306, г. Сергиев Посад, ул. Октябрьская, д. 11

Head of Scientific Research Department. Candidate of Medical Sciences 

Oktyabrskaya Street 11, Sergiev Posad 141306

ЛебедевВ. Н.LebedevV. N.

Лебедев Виталий Николаевич. Ведущий научный сотрудник, д-р биол. наук, проф. 

141306, г. Сергиев Посад, ул. Октябрьская, д. 11

Leading Researcher. Doctor of Biological Sciences, Professor 

Oktyabrskaya Street 11, Sergiev Posad 141306

Федеральное государственное бюджетное учреждение «48 Центральный научно-исследовательский институт» Министерства обороны Российской ФедерацииРоссияFederal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defenсe of the Russian FederationRussian Federation201802072023226169Copyright © Борисевич С.В., Сизикова Т.Е., Сыромятникова С.И., Пантюхов В.Б., Лебедев В.Н., 20232023Борисевич С.В., Сизикова Т.Е., Сыромятникова С.И., Пантюхов В.Б., Лебедев В.Н.Borisevich S.V., Sizikova T.E., Syromyatnikova S.I., Pantukhov V.B., Lebedev V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nbsprot.ru/jour/article/view/195

Эмерджентные вирусные инфекции возникают вследствие спонтанного появления вирулентных для человека штаммов возбудителей инфекционных заболеваний, снижения уровня естественного иммунитета на популяционном уровне, изменений в окружающей среде, способствующих трансмиссии инфекционных заболеваний, повышения уровня контактов между различными регионами. В статье рассмотрены заболевания, вызванные новыми коронавирусами (тяжелый острый респираторный синдром, SARS; Ближневосточный респираторный синдром, MERS), геморрагическая лихорадка Луйо, вызываемая новым аренавирусом с одноименным названием и острая лихорадка с тромбоцитопеническим синдромом, вызываемая новым флебовирусом. Приведены время выявления и идентификации возбудителей, их таксономическая принадлежность, структурная организация генома, возможные пути появления вирулентных для человека штаммов, регион распространения заболеваний, вероятные пути заражения, резервуар инфекции и переносчики, общее количество заболевших и летальность заболевания. Их опасность для здравоохранения обусловлена тяжестью вызываемых заболеваний, отсутствием характерных клинических признаков, что затрудняет проведение диагностики (особенно в неэндемичных регионах), отсутствием средств специфической профилактики и лечения и возможности выявления и идентификации возбудителей только в специализированных научных центрах. Наибольшую угрозу для здравоохранения Российской Федерации в случае завоза их возбудителей на российскую территорию представляют заболевания, вызванные новыми коронавирусами SARS­СoV и MERS­СoV.

The article is dedicated to the review of some hazardous and extremely hazardous emergent viral infections of the beginning of the XXI century – severe acute respiratory syndrome (SARS), Middle­East respiratory syndrome (MERS), Lujo hemorrhagic fever (LHF) and severe fever with thrombocytopenia syndrome (SFTS). Special attention is paid to the time of reveal and identification of infectious agents, their taxonomic belonging, genome organization, possible ways of the appearance of strains, virulent for human beings, to endemic regions, probable ways of infection, reservoirs and transmitters of infection, morbidity and mortality. These infections should be of particular concern because of the severity of illnesses, caused by the above mentioned viruses, the absence of characteristic clinical signs that makes diagnostics more difficult, especially in non­endemic areas, the absence of means of specific prophylaxis and treatment and the difficulties in their identification. The analyze of this emergent viral infections reveals their potential threat for the Armed Forces and population of the Russian Federation in case of accidental or intentional delivery of causative agents of these diseases to the Russian territory.

Ближневосточный респираторный синдромвирулентностьгеморрагическая лихорадка Луйозаболеваемостьидентификация возбудителялетальностьострая лихорадка с тромбоцитопеническим синдромомпереносчикирезервуар инфекциитяжелый острый респираторный синдромэмерджентная вирусная инфекцияMiddle-East respiratory syndromevirulenceLujo hemorrhagic fevermorbidityidentification of agentmortalitysevere fever with thrombocytopenia syndromevectorsreservoir of infectionsevere acute respiratory syndromeemergent viral infectionReferencesDe Groot R.J. Family Coronaviridae / Virus taxonomy, the 9th report of the international committee on taxonomy of viruses. ses / Ed. King AMQ, Adams M.J., Cartens E.B., Lefkowitz E.J. San Diego: Academic Press, 2012. P. 806–828.De Groot R.J. Family Coronaviridae / Virus taxonomy, the 9th report of the international committee on taxonomy of viruses. ses / Ed. King AMQ, Adams M.J., Cartens E.B., Lefkowitz E.J. San Diego: Academic Press, 2012. P. 806–828.Gorbalenya A.E., Enjuanes L., Ziebuhr J., Snijder E.J. Nidovirales: evolving the largest RNA virus genome // Virus Res. 2006. V. 117, № 1. P. 17–37. doi: 10.1016/j.virusres.2006.01.017.Gorbalenya A.E., Enjuanes L., Ziebuhr J., Snijder E.J. Nidovirales: evolving the largest RNA virus genome // Virus Res. 2006. V. 117, № 1. P. 17–37. doi: 10.1016/j.virusres.2006.01.017.Lauber C., Gorbalenya A.E. Partitioning the genetic diversity of a virus family: approach and evaluation through a case study of picornaviruses // J. Virol. 2012. V. 86. № 7. P. 3890–3904. doi:10.1128/JVI.07173-11.Lauber C., Gorbalenya A.E. Partitioning the genetic diversity of a virus family: approach and evaluation through a case study of picornaviruses // J. Virol. 2012. V. 86. № 7. P. 3890–3904. doi:10.1128/JVI.07173-11.Peiris J.S., Yuen K.Y., Osterhaus A.D., Stohr K. The severe acute respiratory syndrome // N. Engl. J. Med. 2003. V. 349. № 25. P. 2431–2441. DOI: 10.1056/NEJMra032498.Peiris J.S., Yuen K.Y., Osterhaus A.D., Stohr K. The severe acute respiratory syndrome // N. Engl. J. Med. 2003. V. 349. № 25. P. 2431–2441. DOI: 10.1056/NEJMra032498.Health Protection Agency. A Case of novel coronavirus identified in the UK. 2013. URL: http://vmw.hpa.org.uk/News Сеntre National Press Releases/2013Pr essReleases/130211statementonlatestcor onavinjspatient (дата обращения: 11.02.2013).Health Protection Agency. A Case of novel coronavirus identified in the UK. 2013. URL: http://vmw.hpa.org.uk/News Сеntre National Press Releases/2013Pr essReleases/130211statementonlatestcor onavinjspatient (дата обращения: 11.02.2013).Zaki A.M., van Boheemen S., Bestebroer T.M. et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia // N. Engl. J. Med. 2012. V. 367. № 19. P. 1814–1820. doi: 10.1056/NEJMoa1211721.Zaki A.M., van Boheemen S., Bestebroer T.M. et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia // N. Engl. J. Med. 2012. V. 367. № 19. P. 1814–1820. doi: 10.1056/NEJMoa1211721.Al Barrak A.M., Stephens G.M., Hewson R. et al. Recovery from severe novel coronavirus infection // J. Saudi Med. 2012. V. 33. № 12. P. 1265–1269.Al Barrak A.M., Stephens G.M., Hewson R. et al. Recovery from severe novel coronavirus infection // J. Saudi Med. 2012. V. 33. № 12. P. 1265–1269.Novel coronavirus – Saudi Arabia. URL: http://www.promedmail.org/direct.рhp?id=20121123.1421664 (дата обращения: 15.09.2015).Novel coronavirus – Saudi Arabia. URL: http://www.promedmail.org/direct.рhp?id=20121123.1421664 (дата обращения: 15.09.2015).Pollack M.P., Pringle C., Madoff L.C., Memish Z.A. Novel coronavirus - Middle East // Int. J. Infect. Dis. 2013. V. 17. № 2. P. 143–144. doi: 10.1016/j.ijid.2012.12.001.Pollack M.P., Pringle C., Madoff L.C., Memish Z.A. Novel coronavirus - Middle East // Int. J. Infect. Dis. 2013. V. 17. № 2. P. 143–144. doi: 10.1016/j.ijid.2012.12.001.Novel Coronavirus - Eastern Mediterranean (04): UK, person to person transmission suspected. . URL: http://www.promedmail.org/directphp?id=20130213.154153 (дата обращения: 11.03.2014).Novel Coronavirus - Eastern Mediterranean (04): UK, person to person transmission suspected. . URL: http://www.promedmail.org/directphp?id=20130213.154153 (дата обращения: 11.03.2014).WHO. Epidemiological update: additional confirmed cases of novel coronavirus including sixth case diagnosed in Europe. URL: http://www.who/int/csr/don/2013_03_27/en/index/html (дата обращения: 132.05.2014).WHO. Epidemiological update: additional confirmed cases of novel coronavirus including sixth case diagnosed in Europe. URL: http://www.who/int/csr/don/2013_03_27/en/index/html (дата обращения: 132.05.2014).Khan G. A novel coronavirus capable of lethal human infections: an emerging picture // J. Virol. 2013. V.10. P. 66. doi.org/10.1186/1743-422X-10-66.Khan G. A novel coronavirus capable of lethal human infections: an emerging picture // J. Virol. 2013. V.10. P. 66. doi.org/10.1186/1743-422X-10-66.Bermingham A. Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. URL: http://www.curosurveillance.org/ViewArticle.aspx (дата обращения: 11.02.2013).Bermingham A. Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. URL: http://www.curosurveillance.org/ViewArticle.aspx (дата обращения: 11.02.2013).European Center for Disease Control. Severe respiratory disease associated with MERS coronavirus. URL: http:///www.ecdr.europa.eu/publications/Publications/MERSupdate 14/02/2014. (дата обращения: 23.02.2015).European Center for Disease Control. Severe respiratory disease associated with MERS coronavirus. URL: http:///www.ecdr.europa.eu/publications/Publications/MERSupdate 14/02/2014. (дата обращения: 23.02.2015).Kossyvakis A., Tao H., Li X., Podka V. et al. Laboratory investigation and phylogenetic analysis of an imported MERS coronavirus case in Greece // PLOS ONE. 2015. V. 10. № 4. P. 1–6. doi: 10.1371/journal.pone.0125809.Kossyvakis A., Tao H., Li X., Podka V. et al. Laboratory investigation and phylogenetic analysis of an imported MERS coronavirus case in Greece // PLOS ONE. 2015. V. 10. № 4. P. 1–6. doi: 10.1371/journal.pone.0125809.Nishiura H., Endo A., Saitoh M., et al. Identifing determinants of the MERS outbreak in the Republic of Korea, 2015: a retrospective epidemiological analysis // BMJ Open. 2016. V. 6. № 2. P. 1–10. doi: 10.1136/bmjopen-2015-009936.Nishiura H., Endo A., Saitoh M., et al. Identifing determinants of the MERS outbreak in the Republic of Korea, 2015: a retrospective epidemiological analysis // BMJ Open. 2016. V. 6. № 2. P. 1–10. doi: 10.1136/bmjopen-2015-009936.Su S., Wong G., Liu Y., Gao G.F., Li S., Bi Y. MERS in South Korea and China: a potential outbreak threat? // Lancet. 2015. V. 385. № 9985. P. 2349–2350. doi: 10.1016/ S0140-6736(15)60859-5.Su S., Wong G., Liu Y., Gao G.F., Li S., Bi Y. MERS in South Korea and China: a potential outbreak threat? // Lancet. 2015. V. 385. № 9985. P. 2349–2350. doi: 10.1016/ S0140-6736(15)60859-5.Vergara-Alert J., van den Brand J.M.A., Widagdo W. et al. Livestock susceptibility to infection with MERS cоronavirus // Emerg. Infect. Dis. 2017. V. 23. № 2. P. 232– 240. DOI: 10.3201/eid2302.161239.Vergara-Alert J., van den Brand J.M.A., Widagdo W. et al. Livestock susceptibility to infection with MERS cоronavirus // Emerg. Infect. Dis. 2017. V. 23. № 2. P. 232– 240. DOI: 10.3201/eid2302.161239.World Health Organization. Middle East respiratory syndrome (MERS-Cov). URL: http://www..int/emergencies/mers-cov/tn//. (дата обращения: 12.06.2015).World Health Organization. Middle East respiratory syndrome (MERS-Cov). URL: http://www..int/emergencies/mers-cov/tn//. (дата обращения: 12.06.2015).World Health Organization Regional office for the Western Pacific. Middle East respiratory syndrome coronavirus – Republic of Korea. URL: http://www.who.int/csr/don/30may2015/mers-korea/en/ (дата обращения: 15.08.2014).World Health Organization Regional office for the Western Pacific. Middle East respiratory syndrome coronavirus – Republic of Korea. URL: http://www.who.int/csr/don/30may2015/mers-korea/en/ (дата обращения: 15.08.2014).Pebody R., Chand M., Thomas H. et al. The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012 // Euro Surveill. 2012. V. 17. № 40. P. 20292.Pebody R., Chand M., Thomas H. et al. The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012 // Euro Surveill. 2012. V. 17. № 40. P. 20292.Woo P.C., Lau S.K., Li K.S. et al. Genetic relatedness of the novel human group С betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5 // Emerg. Microb. Infect. 2012. V. 1. P. 35.Woo P.C., Lau S.K., Li K.S. et al. Genetic relatedness of the novel human group С betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5 // Emerg. Microb. Infect. 2012. V. 1. P. 35.Guan Y., Zheng B.J., He Y.Q. et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China // Science. 2003. V. 302. P. 276–278. DOI:10.1126/science.1087139.Guan Y., Zheng B.J., He Y.Q. et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China // Science. 2003. V. 302. P. 276–278. DOI:10.1126/science.1087139.Tani H., Iha K., Shimojams M. Analysis of Lujo virus using pseudotype vesicular stomatitis virus // J. Virol. 2014. V. 88. № 13. P. 7317-7330. doi: 10.1128/JVI.00512–14.Tani H., Iha K., Shimojams M. Analysis of Lujo virus using pseudotype vesicular stomatitis virus // J. Virol. 2014. V. 88. № 13. P. 7317-7330. doi: 10.1128/JVI.00512–14.Paweska J.T., Sewlall X.N., Ksiazek T.G. et al. Nosocomial outbreak of novel arenavirus infection, Southern Africa // Emerging Inf. Dis. 2009. V. 15. № 10. P. 1596–1602. doi: 10.3201/eid1510.090211.Paweska J.T., Sewlall X.N., Ksiazek T.G. et al. Nosocomial outbreak of novel arenavirus infection, Southern Africa // Emerging Inf. Dis. 2009. V. 15. № 10. P. 1596–1602. doi: 10.3201/eid1510.090211.Buchmeier M.J, de la Torre J.C., Peters C.J. Arenavirdae: viruses and their replication // Fields Virology / Ed. Knipe D.M., Howley P.M. Philadelphia. 2007. P. 1791–1827.Buchmeier M.J, de la Torre J.C., Peters C.J. Arenavirdae: viruses and their replication // Fields Virology / Ed. Knipe D.M., Howley P.M. Philadelphia. 2007. P. 1791–1827.Sewlall N.H., Richards G., Duse A. et al. Clinical features and patient management of Lujo hemorrhagic fever // PLoS Negleted Trop. Dis. 2014. V. 8. № 11. P. 1-11. doi: 10.1371/journal.pntd.0003233.Sewlall N.H., Richards G., Duse A. et al. Clinical features and patient management of Lujo hemorrhagic fever // PLoS Negleted Trop. Dis. 2014. V. 8. № 11. P. 1-11. doi: 10.1371/journal.pntd.0003233.Milazzo M.L., Maria N.B., Cajimat G.D. et al. Transmission of Guanarito and Pirital Viruses among Wild Rodents, Venezuela // Emerg. Infect. Dis. 2011. V. 17. P. 2209–2215. doi: 10.3201/eid1712.110393.Milazzo M.L., Maria N.B., Cajimat G.D. et al. Transmission of Guanarito and Pirital Viruses among Wild Rodents, Venezuela // Emerg. Infect. Dis. 2011. V. 17. P. 2209–2215. doi: 10.3201/eid1712.110393.Tran K., Cimon E., Severn M., et al. Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review // PLoS ONE. 2012. V. 7. P. 1–8. doi: 10.1371/journal.pone.0035797.Tran K., Cimon E., Severn M., et al. Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review // PLoS ONE. 2012. V. 7. P. 1–8. doi: 10.1371/journal.pone.0035797.Cui F., Cao H.F., Wang L. et al. Clinical and epidemiological study on severe fever with thrombocytopenia syndrome in Yiyuan country, Shandong province, China // Am. J. Trop. Med. Hyg. 2013. V. 88. P. 510–512. doi: 10.4269/ajtmh.11-0760.Cui F., Cao H.F., Wang L. et al. Clinical and epidemiological study on severe fever with thrombocytopenia syndrome in Yiyuan country, Shandong province, China // Am. J. Trop. Med. Hyg. 2013. V. 88. P. 510–512. doi: 10.4269/ajtmh.11-0760.Denes S., Janbein J., Nair S., et al. Acute thrombocytopenia, leucopenia and multiorgan dysfunction: the first case of SFTS Bunyavirus outside China? // Hindawi Publ. Corp. Case Rep. Inf. Dis. 2011. P. 1-4. doi:10.1155/2011/204056.Denes S., Janbein J., Nair S., et al. Acute thrombocytopenia, leucopenia and multiorgan dysfunction: the first case of SFTS Bunyavirus outside China? // Hindawi Publ. Corp. Case Rep. Inf. Dis. 2011. P. 1-4. doi:10.1155/2011/204056.Ling F., Zhang W., Wang L.еt al. Epidemiologic feature of severe fever with thrombocytopenia syndrome in China, 2011-2012 // Clin. Infect. Dis. 2013. V. 56. № 11. P. 1682–1683. doi: 10.1093/cid/cit100.Ling F., Zhang W., Wang L.еt al. Epidemiologic feature of severe fever with thrombocytopenia syndrome in China, 2011-2012 // Clin. Infect. Dis. 2013. V. 56. № 11. P. 1682–1683. doi: 10.1093/cid/cit100.Sun Y., Jin C., Zhan C. et al. Host cytokine storm in associated with disease severity of severe fever with thrombocytopenia syndrome // J. Infect. Dis. 2012. P. 1–10. doi 10.1093/infdis/jis452.Sun Y., Jin C., Zhan C. et al. Host cytokine storm in associated with disease severity of severe fever with thrombocytopenia syndrome // J. Infect. Dis. 2012. P. 1–10. doi 10.1093/infdis/jis452.Yu X.J., Liang M.F., Zhang S.Y. et al. Fever with thrombocytopenia associated with novel Bunyavirus in China // New. Eng. J. Med. 2011. V. 364. P. 1523–1532. doi: 10.1056/NEJMoa1010095.Yu X.J., Liang M.F., Zhang S.Y. et al. Fever with thrombocytopenia associated with novel Bunyavirus in China // New. Eng. J. Med. 2011. V. 364. P. 1523–1532. doi: 10.1056/NEJMoa1010095.Lam T., Liu W., Bowden T.A. et al. Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus // Epidemics. 2013. V. 5. № 1. P. 1–10. doi: 10.1016/j.epidem.2012.09.002.Lam T., Liu W., Bowden T.A. et al. Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus // Epidemics. 2013. V. 5. № 1. P. 1–10. doi: 10.1016/j.epidem.2012.09.002.Xu B., Liu L., Huang X. et al. Metagenomic analysis of fever, thrombocytopenia and leucopenia syndrome (FTLS) in Henen province, China: Discovery of a new Bunyavirus // PLOS Patogens. 2011. V. 7. № 11. P. 1–10. doi: 10.1371/journal.ppat.1002369.Xu B., Liu L., Huang X. et al. Metagenomic analysis of fever, thrombocytopenia and leucopenia syndrome (FTLS) in Henen province, China: Discovery of a new Bunyavirus // PLOS Patogens. 2011. V. 7. № 11. P. 1–10. doi: 10.1371/journal.ppat.1002369.Zhang Y.Z., Zhou D.J., Xiong Y. et al. Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiynshan, China // Zhonghua Liu Xing Bing Xue Za Zhi. 2011. V. 32. P. 209-220. PMID: 21457654.Zhang Y.Z., Zhou D.J., Xiong Y. et al. Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiynshan, China // Zhonghua Liu Xing Bing Xue Za Zhi. 2011. V. 32. P. 209-220. PMID: 21457654.Ding F., Guan X.H., Kang K. et al. Risk factors for bunyavirus-associated severe fever with thrombocytopenia syndrome, China // PlOS Negleted Trop. Dis. 2014. V. 8. № 10. P. 1–6. doi: 10.1371/journal.pntd.0003267.Ding F., Guan X.H., Kang K. et al. Risk factors for bunyavirus-associated severe fever with thrombocytopenia syndrome, China // PlOS Negleted Trop. Dis. 2014. V. 8. № 10. P. 1–6. doi: 10.1371/journal.pntd.0003267.Kim K.H., Yi J., Kim G. et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012 // Emerg. Infect. Dis. 2013. V. 19. P. 1892–1894. Doi: org/10.3201/eid1911.130792.Kim K.H., Yi J., Kim G. et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012 // Emerg. Infect. Dis. 2013. V. 19. P. 1892–1894. Doi: org/10.3201/eid1911.130792.Xiong W., Feng Z., Matsui T., Foxwell A.R. Risk assessment of human infection with a novel bunyavirus in China // WPSAR. 2012. V. 3. № 4. P. 61–66. doi: 10.5365/WPSAR.2012.3.4.002.Xiong W., Feng Z., Matsui T., Foxwell A.R. Risk assessment of human infection with a novel bunyavirus in China // WPSAR. 2012. V. 3. № 4. P. 61–66. doi: 10.5365/WPSAR.2012.3.4.002.Jiang X.I., Wang X.J., Li J.D. et al. Isolation, identification and characterization of severe fever with thrombocytopenia syndrome bunyavirus from ticks collected on the surface of domestic animals // J. Chin Virusol. 2012. V. 28. P. 252–257.Jiang X.I., Wang X.J., Li J.D. et al. Isolation, identification and characterization of severe fever with thrombocytopenia syndrome bunyavirus from ticks collected on the surface of domestic animals // J. Chin Virusol. 2012. V. 28. P. 252–257.Zhang Y.Z., Zhou D.J., Qin X.C. et al. The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China // J. Virol. 2012. V. 86. P. 2864–2868. doi: 10.1128/JVI.06192-11.Zhang Y.Z., Zhou D.J., Qin X.C. et al. The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China // J. Virol. 2012. V. 86. P. 2864–2868. doi: 10.1128/JVI.06192-11.Lee K.H., Medlock J.M., Heo S.T. Severe fever with thrombocytopenia syndrome virus, Crimean-Congo hemorrhagic fever virus, and migratory birds // J. Bacteriol. Virol. 2013. V. 43. № 4. P. 235–243. doi.org/10.4167/jbv.2013.43.4.235.Lee K.H., Medlock J.M., Heo S.T. Severe fever with thrombocytopenia syndrome virus, Crimean-Congo hemorrhagic fever virus, and migratory birds // J. Bacteriol. Virol. 2013. V. 43. № 4. P. 235–243. doi.org/10.4167/jbv.2013.43.4.235.Bao C.J., Guo X.L., Qi X. et al. A family cluster of infection by a newly recognized bunyavirus in easern China, 2007: further evidence of person-to-person transmission // Clin. Infect. Dis. 2012. V. 53. № 12. P. 1208– 1214. doi: 10.1093/cid/cir732.Bao C.J., Guo X.L., Qi X. et al. A family cluster of infection by a newly recognized bunyavirus in easern China, 2007: further evidence of person-to-person transmission // Clin. Infect. Dis. 2012. V. 53. № 12. P. 1208– 1214. doi: 10.1093/cid/cir732.Chen H., Hu K., Xiao J. A claster of cases of human-to human transmission caused by severe fever with thrombocytopenia syndrome SFTS bunyavirus // Int. J. Infect Dis. 2013. V. 17. № 3. P. 206–208. doi: 10.1016/j.ijid.2012.11.006.Chen H., Hu K., Xiao J. A claster of cases of human-to human transmission caused by severe fever with thrombocytopenia syndrome SFTS bunyavirus // Int. J. Infect Dis. 2013. V. 17. № 3. P. 206–208. doi: 10.1016/j.ijid.2012.11.006.Gai Z., Liang M., Zhang Y.Z. et al. Person-toperson transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact // Clin. Infect. Dis. 2012. V. 54. № 2. P. 249–252. doi: 10.1093/cid/cir776.Gai Z., Liang M., Zhang Y.Z. et al. Person-toperson transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact // Clin. Infect. Dis. 2012. V. 54. № 2. P. 249–252. doi: 10.1093/cid/cir776.Liu Y., Li Q., Hu W., et al. Person-to-person transmission of SFTS virus // Vector Borne Zoonotic Dis. 2012. V. 12. № 2. P. 156–160. doi.org/10.1089/vbz.2011.0758.Liu Y., Li Q., Hu W., et al. Person-to-person transmission of SFTS virus // Vector Borne Zoonotic Dis. 2012. V. 12. № 2. P. 156–160. doi.org/10.1089/vbz.2011.0758.Tang X., Wu W., Wang H. et al. Humanto human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus through contact with infected blood // J. Infect Dis. 2013. V. 207. № 5. P. 736–739. doi: 10.1093/infdis/jis748.Tang X., Wu W., Wang H. et al. Humanto human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus through contact with infected blood // J. Infect Dis. 2013. V. 207. № 5. P. 736–739. doi: 10.1093/infdis/jis748.

The authors declare that there are no conflicts of interest present.